She was born in Guangzhou. She received her MArch from UC Berkeley and Doctor of Design at Harvard Graduate School of Design. Her research focuses on contemporary urbanism and architecture in the Pearl River Delta, and the specific impact of urbanization on design and practice in China today. Since September 2008, she has been teaching MArch studios at School of Architecture, the Chinese University of Hong Kong; and appointed as Adjunct Associate Professor in 2011. In 2012, Doreen with her firm NODE is shortlisted as one of five international emerging architects for Audi Urban Future Initiative (AUFI) awards; in 2014, Doreen was nominated as Curator for Hong Kong Pavilion for the 14th International Architecture Exhibition – la Biennale di Venezia. She is also a member of the 2015 UABB(SZ) curatorial team.

She established her own design practice NODE (Nansha Original Design) in Hong Kong and Nansha, Guangzhou in 2004, and opened another studio in Shenzhen in 2009. Her built architectural works include Value factory – Main Entrance & Warehouse renovation – Venue A in 2013 Shenzhen/Hong Kong Urbanism/Architectural Bi-city Biennial; Nansha Science Museum, Nansha Bookstore, Guangzhou Times Museum, Lianzhou Int’l Photography Festival Permanent Site & etc. Her design works have been widely published in many international & domestic professional magazines including Architectural Record, Domus, Abitare, Volume and etc. She and her office also have participated in various architectural and art exhibitions including Shanghai Biennale, Guangzhou Triennial, Shenzhen/Hong Kong Urbanism & Architecture Biennale, Venice Biennale and Rotterdam Architectural Biennale, and etc.